DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...