Genes specifying the thiamin monophos¬phate phosphatase and adenylated thiazole diphosphatase steps in fungal and plant thiamin biosynthesis remain unknown, as do genes for thia¬min diphosphate (ThDP) hydrolysis in thiamin metabolism. A distinctive Nudix domain fused to thia¬min di¬phos¬phokin¬ase (Tnr3) in Schizo¬sacc¬¬h¬aromyces pombe was evaluated as a candidate for these funct¬ions....
Genes specifying the thiamin monophosphate phosphatase and adenylated thiazole diphosphatase
steps in fungal and plant thiamin biosynthesis remain unknown, as do genes for thiamin diphosphate
(ThDP) hydrolysis in thiamin metabolism. A distinctive Nudix domain fused to thiamin diphosphokinase
(Tnr3) in Schizosaccharomyces pombe was evaluated as a candidate for these functions....
The objectives of this study were to evaluate the performance of wood-frame shear walls under monotonic and cyclic loads by: 1) determining variability of shear wall performance; 2) comparing performance of walls under each loading protocol; 3) evaluating effects of anchorage on wall perfor-mance; and 4) evaluating performance of walls...
Thiamin diphosphate (ThDP), also known as vitamin B1, serves as an enzymatic cofactor in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis in all living organisms. Unlike plants and microorganisms, humans are not able to synthesize ThDP de novo and must obtain it from their diet. Staple crops...
Thiamin diphosphate (ThDP), also known as vitamin B1, serves as an enzymatic cofactor in glucose metabolism, the Krebs cycle, and branched-chain amino acid biosynthesis in all living organisms. Unlike plants and microorganisms, humans are not able to synthesize ThDP de novo and must obtain it from their diet. Staple crops...
Thiamin is an essential nutrient in the human diet. Severe thiamin deficiency leads to beriberi, a lethal disease which is common in developing countries. Thiamin biofortification of staple food crops is a possible strategy to alleviate thiamin deficiency-related diseases. In plants, thiamin plays a role in the response to abiotic...
Malnutrition is one of the world’s largest health concerns. Folate (also known as vitamin B₉) is essential in the human diet, and without adequate folate intake, several serious health concerns, such as congenital birth defects and an increased risk of stroke and heart disease, can occur. Most people’s folate intake...
Malnutrition is one of the world’s largest health concerns. Folate (a.k.a. vitamin B9) is essential in the human diet and without adequate folate intake several serious health concerns such as congenital birth defects and an increased risk of stroke and heart disease can occur. Most people’s folate intake remains sub-optimal...
Biofortification of folates in staple crops is an important strategy to help eradicate human folate deficiencies. Folate biofortification using genetic engineering has shown great success in rice grain, tomato fruit, lettuce, and potato tuber. However, consumers’ skepticism, juridical hurdles, and lack of economic model have prevented the widespread adoption of...