Index Catalog // ScholarsArchive@OSU

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...
Resource Type:: Article

Creator:: Cardenas, Andres, Houseman, E. Andres, Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mostofa, Golam, Wright, Robert O., Christiani, David C., and Kile, Molly L.
Abstract:: Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Resource Type:: Article

Creator:: Michaud, Dominique S., Houseman, E. Andres, Marsit, Carmen J., Nelson, Heather H., Wiencke, John K., and Kelsey, Karl T.
Abstract:: Understanding the precise role of the immune system in cancer has been hindered by the complexity of the immune response and challenges in measuring immune cell types in health and disease in the context of large epidemiologic studies. In this review, we present the rationale to study immunity in cancer...
Resource Type:: Article

Creator:: Cardenas, Andres, Koestler, Devin C., Houseman, E. Andres, Jackson, Brian P., Kile, Molly L., Karagas, Margaret R., and Marsit, Carmen J.
Abstract:: Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n=37), umbilical artery (n=45) and human...
Resource Type:: Article

Creator:: Cardenas, Andres, Smit, Ellen, Houseman, E. Andres, Kerkvliet, Nancy I., Bethel, Jeffrey W., and Kile, Molly L.
Abstract:: Background: Arsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. Objective: We evaluated the association between arsenic and the seroprevalence of VZV IgG...
Resource Type:: Article

Creator:: Lee, Seung-Tae, Muench, Marcus O., Fomin, Marina E., Xiao, Jianqiao, Zhou, Mi, de Smith, Adam, Martín-Subero, José I., Heath, Simon, Houseman, E. Andres, Roy, Ritu, Wrensch, Margaret, Wiencke, John, Metayer, Catherine, and Wiemels, Joseph L.
Abstract:: We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...
Resource Type:: Article

Creator:: Houseman, E. Andres, Kelsey, Karl T., Wiencke, John K., and Marsit, Carmen J.
Abstract:: BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated. With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is possible to impute cell proportions and adjust for them, but there is increasing interest in...
Resource Type:: Article

Creator:: Accomando, William P., Wiencke, John K., Houseman, E. Andres, Nelson, Heather H., and Kelsey, Karl T.
Abstract:: BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations in virtually any blood sample including...
Resource Type:: Article

Creator:: Poon, Audrey H., Houseman, E. Andres, Ryan, Louise, Sparrow, David, Vokonas, Pantel S., and Litonjua, Augusto A.
Abstract:: BACKGROUND: A substantial proportion of the general population has low lung function, and lung function is known to decrease as we age. Low lung function is a feature of several pulmonary disorders, such as uncontrolled asthma and chronic obstructive pulmonary disease (COPD). The objective of this study is to investigate...
Resource Type:: Article

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...
Resource Type:: Article

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