Index Catalog // ScholarsArchive@OSU

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...

Creator:: Houseman, E. Andres, Kelsey, Karl T., Wiencke, John K., and Marsit, Carmen J.
Abstract:: BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated. With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is possible to impute cell proportions and adjust for them, but there is increasing interest in...

Creator:: Houseman, E. Andres, Kelsey, Karl T., Wiencke, John K., and Marsit, Carmen J.
Abstract:: BACKGROUND: The impact of cell-composition effects in analysis of DNA methylation data is now widely appreciated. With the availability of a reference data set consisting of DNA methylation measurements on isolated cell types, it is possible to impute cell proportions and adjust for them, but there is increasing interest in...

Creator:: Lee, Seung-Tae, Muench, Marcus O., Fomin, Marina E., Houseman, E. Andres, and et al.
Abstract:: We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...

Creator:: Lee, Seung-Tae, Muench, Marcus O., Fomin, Marina E., Houseman, E. Andres, and et al.
Abstract:: We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...

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