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Filtering by: Creator Lu, Wanli License Attribution 4.0 (CC BY 4.0)

Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Creator:

Guha, Gunjan, Lu, Wanli, Li, Shan, Liang, Xiaobo, Kulesz-Martin, Molly F., Mahmud, Taifo, Indra, Arup Kumar, and Ganguli-Indra, Gitali

Abstract:

Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...

Resource Type:

Article