Index Catalog // ScholarsArchive@OSU

Creator:: Sheng, Yan, Lam, Phillip W., Shahab, Salmah, Santosa, Dwi Andreas, Proteau, Philip J., Zabriskie, T. Mark, and Mahmud, Taifo
Abstract:: Four new elaiophylin macrolides (1–4), together with five known elaiophylins (5–9), have been isolated from cultures of the Indonesian soil bacterium Streptomyces sp. ICBB 9297. The new compounds have macrocyclic skeletons distinct from those of the known dimeric elaiophylins in that one or both of the polyketide chains contain(s) an...
Resource Type:: Article

Creator:: Nigam, Aeshna, Almabruk, Khaled H., Saxena, Anjali, Yang, Jongtae, Mukherjee, Udita, Kaur, Hardeep, Kohli, Puneet, Kumari, Rashmi, Singh, Priya, Zakharov, Lev N., Singh, Yogendra, Mahmud, Taifo, and Lal, Rup
Abstract:: Rifamycin B, a product of Amycolatopsis mediterranei S699, is the precursor of clinically used antibiotics that are effective against tuberculosis, leprosy and AIDS related mycobacterial infections. However, prolonged usage of these antibiotics has resulted in the emergence of rifamycin resistant strains of Mycobacterium tuberculosis. As part of our effort to...
Resource Type:: Article

Creator:: Kean, Kelsey M., Codding, Sara J., Asamizu, Shumpei, Mahmud, Taifo, and Karplus, P. Andrew
Abstract:: Sedoheptulose 7-phosphate cyclases (SH7PCs) encompass three enzymes involved in producing the core cyclitol structures of pseudoglycosides and similar bioactive natural products. One such enzyme is ValA from Streptomyces hygroscopicus subsp. jinggangensis 5008 which makes 2-epi-5-epi-valiolone as part of the biosynthesis of the agricultural antifungal agent validamycin A. We present, as...
Resource Type:: Article

Creator:: Xie, Pengfei, Sheng, Yan, Ito, Takuya, and Mahmud, Taifo
Abstract:: Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and anti-neoplastic activities. However, its production in the wild-type strain of Streptomyces nodosus subsp. asukaensis ATCC 29757 is relatively low. Recently, the biosynthetic gene cluster for asukamycin was identified in the producing organism and among the 36...
Resource Type:: Article

ScholarsArchive@OSU