The role of the yeast S-adenosylmethionine: Δ²⁴-sterol-C-methyltransferase
(SCMT) in sterol metabolism was investigated.
Structural analogs of S-adenosylhomocysteine were tested for
inhibition of the SCMT enzyme. A wide inhibitory range by these
compounds was observed, indicating which structural features of the
parent compound are important for binding to the enzyme. The...