Index Catalog // ScholarsArchive@OSU

Creator:: Speight, Lee C., Muthusamy, Anand K., Goldberg, Jacob M., Warner, John B., Wissner, Rebecca F., Willi, Taylor S., Woodman, Bradley F., Mehl, Ryan A., and Petersson, E. James
Abstract:: The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...

Creator:: Speight, Lee C., Muthusamy, Anand K., Goldberg, Jacob M., Warner, John B., Wissner, Rebecca F., Willi, Taylor S., Woodman, Bradley F., Mehl, Ryan A., and Petersson, E. James
Abstract:: The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...

Creator:: Gu, Xiaodong, Wu, Zhiping, Huang, Ying, Wagner, Matthew A., Baleanu-Gogonea, Camelia, Mehl, Ryan A., Buffa, Jennifer A., DiDonato, Anthony J., Hazen, Leah B., Fox, Paul L., Gogonea, Valentin, Parks, John S., DiDonato, Joseph A., and Hazen, Stanley L.
Abstract:: The interaction of lecithin-cholesterol acyltransferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in highdensity lipoprotein (HDL) maturation.Wepreviously identified a highly solvent-exposed apoA-I loop domain (Leu¹⁵⁹–Leu¹⁷⁰) in nascent HDL, the so-called “solar flare” (SF) region, and proposed that it serves as an LCAT docking site (Wu, Z., Wagner, M....
Resource Type:: Article

Creator:: Speight, Lee C., Muthusamy, Anand K., Goldberg, Jacob M., Warner, John B., Wissner, Rebecca F., Willi, Taylor S., Woodman, Bradley F., Mehl, Ryan A., and Petersson, E. James
Abstract:: The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
Resource Type:: Article

Creator:: Cooley, Richard B., Karplus, P. Andrew, and Mehl, Ryan A.
Abstract:: The site-specific incorporation of non-canonical amino acids (ncAAs) into proteins is an important tool for understanding biological function. Traditionally, each new ncAA targeted requires a resource-consuming process of generating new ncAA aminoacyl tRNA synthetase/tRNACUA pairs. However, the discovery that some tRNA synthetases are “permissive,” in that they can incorporate multiple...
Resource Type:: Article

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