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Filtering by: Creator Mourich, Dan V. Language English [eng]

Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery

Creator:

Panchal, Rekha G., Mourich, Dan V., Bradfute, Steven, Hauck, Laura L., Warfield, Kelly L., Iversen, Patrick L., and Bavari, Sina

Abstract:

Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10 [superscript -...

Resource Type:

Article
Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease

Creator:

Schnell, Frederick J., Sundholm, Sarah, Crumley, Stacy, Iversen, Patrick L., and Mourich, Dan V.

Abstract:

The viral family Arenaviridae includes a number of viruses that can cause hemorrhagic fever in humans. Arenavirus infection often involves multiple organs and can lead to capillary instability, impaired hemostasis, and death. Preclinical testing for development of antiviral or therapeutics is in part hampered due to a lack of an...

Resource Type:

Article
Analysis of immune modulators in rainbow trout (Oncorhynchus mykiss)

Creator:

Mourich, Dan V.

Abstract:

The immune systems of various teleost fish have been studied in some detail for the past several decades. One aspect of fish immunity, that of endogenously produced modulating factors, has recently received a great deal of attention. Understanding the functions and roles of endogenous factors that regulate fish immunity is...

Resource Type:

Dissertation