Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
Intrinsically disordered proteins (IDPs) are prevalent in macromolecular assemblies and are
thought to mediate protein recognition in complex regulatory processes and signaling pathways. The
formation of a polybivalent scaffold is a key process by which IDPs drive early steps in macromolecular
assemblies. Three intrinsically disordered proteins, IC, Swallow and Nup159,...
Intrinsically disordered proteins (IDPs) are prevalent in macromolecular assemblies and are
thought to mediate protein recognition in complex regulatory processes and signaling pathways. The
formation of a polybivalent scaffold is a key process by which IDPs drive early steps in macromolecular
assemblies. Three intrinsically disordered proteins, IC, Swallow and Nup159,...
Intrinsically disordered proteins (IDPs) are prevalent in macromolecular assemblies and are thought to mediate protein recognition in complex regulatory processes and signaling pathways. The formation of a polybivalent scaffold is a key process by which IDPs drive early steps in macromolecular assemblies. Three intrinsically disordered proteins, IC, Swallow and Nup159,...
The following corrections appear in the attached pdf labelled "Correction to Version of Record". The authors inadvertently omitted Woonghee Lee from the list of authors. The corrected author list and affiliations are noted. Revised acknowledgment paragraphs including Woonghee Lee’s funding source and contribution also appear in the correction.
In addition,...