Index Catalog // ScholarsArchive@OSU

Creator:: Minato, Yusuke, Fassio, Sara R., Kirkwood, Jay S., Halang, Petra, Quinn, Matthew J., Faulkner, Wyatt J., Aagesen, Alisha M., Steuber, Julia, Stevens, Jan F., and Häse, Claudia C.
Abstract:: The Na⁺ translocating NADH:quinone oxidoreductase (Na⁺-NQR) is a unique respiratory enzyme catalyzing the electron transfer from NADH to quinone coupled with the translocation of sodium ions across the membrane. Typically, Vibrio spp., including Vibrio cholerae, have this enzyme but lack the proton-pumping NADH:ubiquinone oxidoreductase (Complex I). Thus, Na⁺-NQR should significantly...
Resource Type:: Article

Creator:: Fassio, Sara R., Minato, Yusuke, Quinn, Matthew J., Faulkner, Wyatt J., and Hase, Claudia C.
Abstract:: We previously reported that inhibition of the Na⁺ translocating NADH:ubiquinone oxidoreductase (NQR), either by chemical inhibition or mutation, increased toxT transcription in Vibrio cholerae. In this study, we revealed that the nqr mutant strain showed similar phenotypes as the Escherichia coli NADH dehydrogenase I (nuo) mutant strain (e.g. growth defect...
Resource Type:: Poster

Creator:: Quinn, Matthew J., Resch, Craig T., Sun, Jonathan, Lind, Erin J., Dibrov, Pavel, and Hase, Claudia C.
Abstract:: Vibrio cholerae has adapted to a wide range of salinity, pH and osmotic conditions, enabling it to survive passage through the host and persist in the environment. Among the many proteins responsible for bacterial survival under these diverse conditions, we have identified Vc-NhaP1 as a K+(Na+)/H+ antiporter essential for V....
Resource Type:: Article

Creator:: Quinn, Matthew J.
Abstract:: The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
Resource Type:: Dissertation

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