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Filtering by: Creator Smits, Helmars Remove constraint Creator: Smits, Helmars Subject Microbial metabolites -- Synthesis Remove constraint Subject: Microbial metabolites -- Synthesis

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  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation