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  • Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

    Creator:
    Spiro, Craig
    Abstract:
    Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
    Resource Type:
    Dissertation