The protein palmitoylation cycle has been shown to be important for protein signaling and synaptic plasticity. Data from our lab showed a change in the palmitoylation status of certain proteins with age. A greater percentage of the NMDA receptor subunits GluN2A and GluN2B, along with Fyn and PSD95 proteins, were...
Meadowfoam (Limnanthes alba) is a commercial oilseed annual crop
grown in Oregon. After extracting oil from seed, the remaining seed
meal is rich in the secondary plant metabolite glucolimnanthin, which
can be converted into pesticidal compounds such as 3-methoxybenzyl
isothiocyanate (ITC) and 3-methoxyphenylacetonitrile (nitrile) in the
presence of the enzyme...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...