Considerable progress ha been made in Computer-Aided Design (CAD) techniques to assist Mechanical Engineers in the detail design stages and adaptive redesign tasks. Currently, CAD tools support the designer in system layouts, sizing of components, drafting, analytical calculations, generating NC machining data and even motion or energy simulations. However, the...
Avermectin Bia is a member of a class of medicinally important
natural products known for its potent antiparasitic activity and
interesting structural features. In this thesis, synthesis of a
model for the spiroketal portion of the avermectins is presented.
Oxidation of (S)-2-methylbutanol, followed by a stereoselective
chromium mediated reaction with...