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Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article

Creator:: Hackman, Kayla M., Doddapaneni, Bhuvana Shyam, Barth, Connor W., Wierzbicki, Igor H., Alani, Adam W. G., and Gibbs, Summer L.
Abstract:: ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Resource Type:: Article

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

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