Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and
pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in
natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase...
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Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression
Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures
have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of
individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions
of environmentally...
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carcinogenesis?
Robey, R. B., Weisz, J., Kuemmerle, N., Salzberg, A. C., Berg, A., Brown, D.
G., ... & Ryan, E
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
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MC, Thanataveerat A, et al. Cost-effectiveness of hypertension therapy accord-
ing to 2014 guidelines
Stream-dwelling species in the U.S. southern Appalachian Mountains region are particularly vulnerable to climate change and acidification. The objectives of this study were to quantify the spatial extent of contemporary suitable habitat for acid- and thermally sensitive aquatic species and to forecast future habitat loss resulting from expected temperature increases...
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., Sullivan, T. J., Dolloff, C. A., Hessburg, P. F.,
Povak, N. A., ... & Sams, C. (2015). Downstream Warming
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
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Shakun, J. D., Clark, P. U., He, F., Lifton, N. A., Liu, Z., & Otto-Bliesner, B. L.
(2015). Regional and
Altimeter sea surface height (SSH) fields are analyzed to define and discuss the seasonal circulation
over the wide continental shelf in the SW Atlantic Ocean (27°–43°S) during 2001–2012. Seasonal variability
is low south of the Rio de la Plata (RdlP), where winds and currents remain equatorward for most of
the...
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:
27°–43°S
Strub, P. T., James, C., Combes, V., Matano, R. P., Piola, A. R., Palma, E. D., ...
& Ruiz
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
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that allows appropriate data display. Each author should submit a separate
form and is responsible
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
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Immunization and Primary Health Care: A
Mixed-Methods Study
Web Supplement
TABLE OF CONTENTS
The ongoing retreat of glaciers globally is one of the clearest manifestations of recent global warming associated with rising greenhouse gas concentrations. By comparison, the importance of greenhouse gases in driving glacier retreat during the most recent deglaciation, the last major interval of global warming, is unclear due to uncertainties...
Full Text:
a younger population (J. Licciardi, pers. comm., 2012)
*****Following Licciradi et al. (2004