Much uncertainty exists about the state of the oceanic and atmospheric circulation in the tropical Pacific over the last glacial cycle. Studies have been hampered by the fact that sediment cores suitable for study were concentrated in the western and eastern parts of the tropical Pacific, with little information from...
Much uncertainty exists about the state of the oceanic and atmospheric circulation in the tropical Pacific over the last glacial cycle. Studies have been hampered by the fact that sediment cores suitable for study were concentrated in the western and eastern parts of the tropical Pacific, with little information from...
Altimeter sea surface height (SSH) fields are analyzed to define and discuss the seasonal circulation
over the wide continental shelf in the SW Atlantic Ocean (27°–43°S) during 2001–2012. Seasonal variability
is low south of the Rio de la Plata (RdlP), where winds and currents remain equatorward for most of
the...
Altimeter sea surface height (SSH) fields are analyzed to define and discuss the seasonal circulation
over the wide continental shelf in the SW Atlantic Ocean (27°–43°S) during 2001–2012. Seasonal variability
is low south of the Rio de la Plata (RdlP), where winds and currents remain equatorward for most of
the...
The abundance of microbial life and the sources of energy necessary for deep subsurface microbial communities remain enigmatic. Here we investigate deep microbial processes and their potential relationships to tectonic events in sediments from the Nankai Trough offshore Japan, drilled and sampled during IODP (Integrated Ocean Drilling Program) Expedition 316....
The abundance of microbial life and the sources of energy necessary for deep subsurface microbial communities remain enigmatic. Here we investigate deep microbial processes and their potential relationships to tectonic events in sediments from the Nankai Trough offshore Japan, drilled and sampled during IODP (Integrated Ocean Drilling Program) Expedition 316....
Time-series observations are critical to understand the structure, function, and dynamics of marine ecosystems. The Hawaii Ocean Time-series program has maintained near-monthly sampling at Station ALOHA (22°45′N, 158°00′W) in the oligotrophic North Pacific Subtropical Gyre (NPSG) since 1988 and has identified ecosystem variability over seasonal to interannual timescales. To further...
Time-series observations are critical to understand the structure, function, and dynamics of marine ecosystems. The Hawaii Ocean Time-series program has maintained near-monthly sampling at Station ALOHA (22°45′N, 158°00′W) in the oligotrophic North Pacific Subtropical Gyre (NPSG) since 1988 and has identified ecosystem variability over seasonal to interannual timescales. To further...
Interpretation of ice core trace gas records depends on an accurate understanding of the
processes that smooth the atmospheric signal in the firn. Much work has been done to understand the
processes affecting air transport in the open pores of the firn, but a paucity of data from air trapped...
Interpretation of ice core trace gas records depends on an accurate understanding of the
processes that smooth the atmospheric signal in the firn. Much work has been done to understand the
processes affecting air transport in the open pores of the firn, but a paucity of data from air trapped...
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
BACKGROUND: On the basis of the 2014 guidelines for hypertension therapy in the United States,
many eligible adults remain untreated. We projected the cost-effectiveness of treating
hypertension in U.S. adults according to the 2014 guidelines.
METHODS: We used the Cardiovascular Disease Policy Model to simulate drug-treatment and
monitoring costs, costs...
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
Climate-driven changes in biotic interactions can profoundly alter ecological
communities, particularly when they impact foundation species. In marine systems,
changes in herbivory and the consequent loss of dominant habitat forming species can
result in dramatic community phase shifts, such as from coral to macroalgal
dominance when tropical fish herbivory decreases,...
Climate-driven changes in biotic interactions can profoundly alter ecological
communities, particularly when they impact foundation species. In marine systems,
changes in herbivory and the consequent loss of dominant habitat forming species can
result in dramatic community phase shifts, such as from coral to macroalgal
dominance when tropical fish herbivory decreases,...
Capture-recapture studies offer a powerful tool to assess abundance, survival and population rate of change (λ). A previous capture-recapture study, based on DNA profiles, estimated that the IUCN-listed Endangered Oceania population of humpback whales had a superpopulation size of 4329 whales (95% confidence limits, CL: 3345, 5315) and λ =...
Capture-recapture studies offer a powerful tool to assess abundance, survival and population rate of change (λ). A previous capture-recapture study, based on DNA profiles, estimated that the IUCN-listed Endangered Oceania population of humpback whales had a superpopulation size of 4329 whales (95% confidence limits, CL: 3345, 5315) and λ =...
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
Large amount of organic carbon is stored in high latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
Large amount of organic carbon is stored in high latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
A large amount of organic carbon is stored in high-latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
A large amount of organic carbon is stored in high-latitude soils. A substantial proportion of this carbon stock is vulnerable and may decompose rapidly due to temperature increases that are already greater than the global average. It is therefore crucial to quantify and understand carbon exchange between the atmosphere and...
The Plant Ontology Consortium (POC, http://www.plantontology.org) is a collaborative effort
among model plant genome databases and plant
researchers that aims to create, maintain and
facilitate the use of a controlled vocabulary
(ontology) for plants. The ontology allows users to
ascribe attributes of plant structure (anatomy and
morphology) and developmental stages...
The Plant Ontology Consortium (POC, http://www.plantontology.org) is a collaborative effort
among model plant genome databases and plant
researchers that aims to create, maintain and
facilitate the use of a controlled vocabulary
(ontology) for plants. The ontology allows users to
ascribe attributes of plant structure (anatomy and
morphology) and developmental stages...
The Plant Ontology Consortium (POC, http://www.plantontology.org) is a collaborative effort
among model plant genome databases and plant
researchers that aims to create, maintain and
facilitate the use of a controlled vocabulary
(ontology) for plants. The ontology allows users to
ascribe attributes of plant structure (anatomy and
morphology) and developmental stages...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The relative influences of trans-Pacific and regional atmospheric transport on measured concentrations of polycyclic aromatic hydrocarbons (PAHs), PAH derivatives [Nitro- (NPAH) and Oxy-(OPAH)], organic carbon (OC), and Particulate Matter (PM) less than 2.5 μm in diameter (PM₂.₅) were investigated in the Pacific Northwest, USA in 2010-2011. Ambient high volume PM₂.₅...
The relative influences of trans-Pacific and regional atmospheric transport on measured concentrations of polycyclic aromatic hydrocarbons (PAHs), PAH derivatives [Nitro- (NPAH) and Oxy-(OPAH)], organic carbon (OC), and Particulate Matter (PM) less than 2.5 μm in diameter (PM₂.₅) were investigated in the Pacific Northwest, USA in 2010-2011. Ambient high volume PM₂.₅...
Trophic interactions within and among species vary widely across spatial scales and species’ ontogeny. However, the drivers and implications of this variability are not well understood. Juvenile Chinook salmon Oncorhynchus tshawytscha have a wide distribution, ranging from northern California to the eastern Bering Sea in North America, but it is...
Trophic interactions within and among species vary widely across spatial scales and species’ ontogeny. However, the drivers and implications of this variability are not well understood. Juvenile Chinook salmon Oncorhynchus tshawytscha have a wide distribution, ranging from northern California to the eastern Bering Sea in North America, but it is...
To determine how well DNA barcodes from the chloroplast region perform in forest dynamics plots
(FDPs) from global CTFS-ForestGEO network, we analyzed DNA barcoding sequences of 1277 plant
species from a wide phylogenetic range (3 FDPs in tropics, 5 in subtropics and 5 in temperate zone)
and compared the rates...
To determine how well DNA barcodes from the chloroplast region perform in forest dynamics plots
(FDPs) from global CTFS-ForestGEO network, we analyzed DNA barcoding sequences of 1277 plant
species from a wide phylogenetic range (3 FDPs in tropics, 5 in subtropics and 5 in temperate zone)
and compared the rates...
Inherited bone marrow failure syndromes (IBMFS) including Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome are rare genetic disorders characterized by hematologic complications and increased risk of cancer. Patients and their families likely experience obstacles in obtaining sufficient health information given their disorders’ rarity. To investigate this possibility, we...
Inherited bone marrow failure syndromes (IBMFS) including Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome are rare genetic disorders characterized by hematologic complications and increased risk of cancer. Patients and their families likely experience obstacles in obtaining sufficient health information given their disorders’ rarity. To investigate this possibility, we...
Background:
Mapping and map-based cloning of genes that control agriculturally and economically important traits remain great challenges for plants with complex highly repetitive genomes such as those within the grass tribe, Triticeae. Mapping limitations in the Triticeae are primarily due to low frequencies of polymorphic gene markers and poor genetic...
Background:
Mapping and map-based cloning of genes that control agriculturally and economically important traits remain great challenges for plants with complex highly repetitive genomes such as those within the grass tribe, Triticeae. Mapping limitations in the Triticeae are primarily due to low frequencies of polymorphic gene markers and poor genetic...
Resolving the debate surrounding the nature and controls of seasonal variation in the structure and metabolism of Amazonian rainforests is critical to understanding their response to climate change. In situ studies have observed higher photosynthetic and evapotranspiration rates, increased litterfall and leaf flushing during the Sunlight-rich dry season. Satellite data...
Resolving the debate surrounding the nature and controls of seasonal variation in the structure and metabolism of Amazonian rainforests is critical to understanding their response to climate change. In situ studies have observed higher photosynthetic and evapotranspiration rates, increased litterfall and leaf flushing during the Sunlight-rich dry season. Satellite data...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
The Luzon Strait is the generation region for strong internal tides that radiate westward into the South China Sea and eastward into the western Pacific. Intrusions of the Kuroshio and strong mesoscale variability in the Luzon Strait can influence their generation and propagation. Here, the authors use eight moorings and...
The Luzon Strait is the generation region for strong internal tides that radiate westward into the South China Sea and eastward into the western Pacific. Intrusions of the Kuroshio and strong mesoscale variability in the Luzon Strait can influence their generation and propagation. Here, the authors use eight moorings and...
Species distribution models (SDMs) are increasingly applied in conservation management
to predict suitable habitat for poorly known populations. High predictive performance of
SDMs is evident in validations performed within the model calibration area (interpolation),
but few studies have assessed SDM transferability to novel areas (extrapolation), particularly
across large spatial scales...
Species distribution models (SDMs) are increasingly applied in conservation management
to predict suitable habitat for poorly known populations. High predictive performance of
SDMs is evident in validations performed within the model calibration area (interpolation),
but few studies have assessed SDM transferability to novel areas (extrapolation), particularly
across large spatial scales...
Ocean acidification is a global, long-term problem whose ultimate solution requires carbon dioxide reduction at a scope and
scale that will take decades to accomplish successfully. Until that is achieved, feasible and locally relevant adaptation and
mitigation measures are needed. To help to prioritize societal responses to ocean acidification, we...
Ocean acidification is a global, long-term problem whose ultimate solution requires carbon dioxide reduction at a scope and
scale that will take decades to accomplish successfully. Until that is achieved, feasible and locally relevant adaptation and
mitigation measures are needed. To help to prioritize societal responses to ocean acidification, we...
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
BACKGROUND: After 2 decades of focused efforts to eradicate polio, the impact of eradication activities on health
systems continues to be controversial. This study evaluated the impact of polio eradication activities on routine immunization
(RI) and primary healthcare (PHC).
METHODS: Quantitative analysis assessed the effects of polio eradication campaigns on...
BACKGROUND: Occupational exposure to extremely low frequency magnetic fields (ELF) is a
suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have
assessed whether ELF in different time windows of exposure may be associated with specific
histologic types of brain tumours. This study examines the association...
BACKGROUND: Occupational exposure to extremely low frequency magnetic fields (ELF) is a
suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have
assessed whether ELF in different time windows of exposure may be associated with specific
histologic types of brain tumours. This study examines the association...
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that...
Phytophthora infestans, the causal agent of late blight disease, has been reported in North America since the mid-nineteenth century. In the United States the lack of or very limited sexual reproduction has resulted in largely clonal populations of P. infestans. In 2010 and 2011, but not in 2012 or 2013,...
Phytophthora infestans, the causal agent of late blight disease, has been reported in North America since the mid-nineteenth century. In the United States the lack of or very limited sexual reproduction has resulted in largely clonal populations of P. infestans. In 2010 and 2011, but not in 2012 or 2013,...
Advances in forest carbon mapping have the potential
to greatly reduce uncertainties in the global carbon
budget and to facilitate effective emissions mitigation strategies
such as REDDC (Reducing Emissions from Deforestation
and Forest Degradation). Though broad-scale mapping
is based primarily on remote sensing data, the accuracy of
resulting forest carbon...
Advances in forest carbon mapping have the potential
to greatly reduce uncertainties in the global carbon
budget and to facilitate effective emissions mitigation strategies
such as REDDC (Reducing Emissions from Deforestation
and Forest Degradation). Though broad-scale mapping
is based primarily on remote sensing data, the accuracy of
resulting forest carbon...
Cytogenetic chromosome maps offer molecular tools for genome analysis and clinical cytogenetics and are of particular
importance for species with difficult karyotypes, such as camelids (2n = 74). Building on the available human-camel zoo-fluorescence
in situ hybridization (FISH) data, we developed the first cytogenetic map for the alpaca (Lama pacos,...
Cytogenetic chromosome maps offer molecular tools for genome analysis and clinical cytogenetics and are of particular
importance for species with difficult karyotypes, such as camelids (2n = 74). Building on the available human-camel zoo-fluorescence
in situ hybridization (FISH) data, we developed the first cytogenetic map for the alpaca (Lama pacos,...
Cytogenetic chromosome maps offer molecular tools for genome analysis and clinical cytogenetics and are of particular
importance for species with difficult karyotypes, such as camelids (2n = 74). Building on the available human-camel zoo-fluorescence
in situ hybridization (FISH) data, we developed the first cytogenetic map for the alpaca (Lama pacos,...
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
We present multiple lines of evidence for years to decade-long changes in the location and
character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus
in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
We present multiple lines of evidence for years to decade-long changes in the location and
character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus
in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Resazurin (Raz) and its reaction product resorufin
(Rru) have increasingly been used as reactive tracers to quantify
metabolic activity and hyporheic exchange in streams.
Previous work has indicated that these compounds undergo
sorption in stream sediments. We present laboratory experiments
on Raz and Rru transport, sorption, and transformation,
consisting of...
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
Circadian clocks coordinate physiological, neurological, and behavioral functions into circa 24 hour rhythms, and the
molecular mechanisms underlying circadian clock oscillations are conserved from Drosophila to humans. Clock oscillations
and clock-controlled rhythms are known to dampen during aging; additionally, genetic or environmental clock disruption
leads to accelerated aging and increased...
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
The goal of this project was to investigate the effects and possible developmental disease implication of chronic dietary
TCDD exposure on global gene expression anchored to histopathologic analysis in juvenile zebrafish by functional genomic,
histopathologic and analytic chemistry methods. Specifically, juvenile zebrafish were fed Biodiet starter with TCDD added at...
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
Fungal hyphae are among the most highly polarized cells. Hyphal polarized
growth is supported by tip-directed transport of secretory vesicles, which accumulate temporarily
in a stratified manner in an apical vesicle cluster, the Spitzenkörper. The exocyst complex
is required for tethering of secretory vesicles to the apical plasma membrane. We...
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have
made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase
genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest...
Repetitive sequences present a challenge for genome sequence assembly, and highly similar segmental duplications may
disappear from assembled genome sequences. Having found a surprising lack of observable phenotypic deviations and
non-Mendelian segregation in Arabidopsis thaliana mutants in SEC10, a gene encoding a core subunit of the exocyst
tethering complex, we...
Repetitive sequences present a challenge for genome sequence assembly, and highly similar segmental duplications may
disappear from assembled genome sequences. Having found a surprising lack of observable phenotypic deviations and
non-Mendelian segregation in Arabidopsis thaliana mutants in SEC10, a gene encoding a core subunit of the exocyst
tethering complex, we...
New sources of genetic diversity must be incorporated into plant breeding programs if they are to continue increasing grain
yield and quality, and tolerance to abiotic and biotic stresses. Germplasm collections provide a source of genetic and
phenotypic diversity, but characterization of these resources is required to increase their utility...
New sources of genetic diversity must be incorporated into plant breeding programs if they are to continue increasing grain
yield and quality, and tolerance to abiotic and biotic stresses. Germplasm collections provide a source of genetic and
phenotypic diversity, but characterization of these resources is required to increase their utility...
The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the final product BS. Incomplete conversion...
The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the final product BS. Incomplete conversion...
Mangroves provide a wide range of ecosystem services, including nutrient cycling, soil formation, wood production, fish spawning grounds, ecotourism and carbon (C) storage¹. High rates of tree and plant growth, coupled with anaerobic, water-logged soils that slow decomposition, result in large long-term C storage. Given their global significance as large...
Mangroves provide a wide range of ecosystem services, including nutrient cycling, soil formation, wood production, fish spawning grounds, ecotourism and carbon (C) storage¹. High rates of tree and plant growth, coupled with anaerobic, water-logged soils that slow decomposition, result in large long-term C storage. Given their global significance as large...
Iron (Fe) and copper (Cu) are essential cofactors for microbial metalloenzymes, but little is known about the metalloenyzme inventory of anaerobic marine microbial communities despite their importance to the nitrogen cycle. We compared dissolved O₂ , NO₃⁻, NO₂⁻, Fe and Cu concentrations with nucleic acid sequences encoding Fe and Cu-binding...