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Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold

Creator:

Gaik, Monika, Flemming, Dirk, von Appen, Alexander, Kastritis, Panagiotis, Mücke, Norbert, Fischer, Jessica, Stelter, Philipp, Ori, Alessandro, Bui, Khanh Huy, Baßler, Jochen, Barbar, Elisar, Beck, Martin, and Hurt, Ed

Abstract:

Nuclear pore complexes (NPCs) are huge assemblies formed from ~30 different nucleoporins, typically organized in subcomplexes. One module, the conserved Nup82 complex at the cytoplasmic face of NPCs, is crucial to terminate mRNA export. To gain insight into the structure, assembly, and function of the cytoplasmic pore filaments, we reconstituted...

Resource Type:

Article