In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate) metabolism have demonstrated that at least three ether soluble metabolites are formed in a microsomal system fortified with reduced triphosphopyridine nucleotide (NADPH). One of the metabolites was identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam. The other two metabolites did not possess...
In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate)
metabolism have demonstrated that at least three ether soluble
metabolites are formed in a microsomal system fortified with reduced
triphosphopyridine nucleotide (NADPH). One of the metabolites was
identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam.
The other two metabolites did not possess...
Studies were initially conducted to determine the action of
intravenous serotonin on perfused segments of human umbilical
cords in vitro. Intravenous serotonin, via bolus injection or
continuous infusion, was found to elevate venous perfusion pressure,
while intra-arterial serotonin failed to alter venous pressure.
Norepinephrine, administered to the venous perfusate, was...
Temperature effects on osmoregulation were studied in larval
Ambystoma gracile. There was a pronounced effect on the osmotic
uptake of water through the skin. The rates at 5°C, 15°C and 25°C
were respectively 0.03 ml/hr., 0.1 ml/hr. and 0.2 ml/hr. for a
10g animal. The Q₁₀'s for these changes in...
This thesis examines various net or finite difference methods
for solving parabolic partial differential equations in one space variable
with constant coefficients. Included in this investigation are
explicit, implicit and multi-step methods of varying orders of accuracy.
These methods are compared with respect to accuracy, speed,
efficiency, stability, simplicity of...
The production of C¹⁴O₂ metabolized from glucose labeled in
specific carbon atoms by homogenates of chick embryonic and adult
heart was compared by the radiorespirometric technique. Homogenates
of early (two to five days of incubation) embryo hearts were
found to utilize the phosphogluconate pathway of glucose catabolism
to a greater...
The two naturally occurring cyclopropene fatty acids, sterculic
and malvalic, have been synthesized. The cyclopropene ring was
made by inserting a methylene unit into an acetylenic linkage.
The synthesis of methyl sterculate was repeated using diethyl
aluminum chloride, diazomethane, and methyl stearolate.
Methyl malvalate was totally synthesized. Diethyl malonate
was...
This thesis introduces a technique for approximating to a desired
degree of accuracy a linear parabolic equation of two spatial
dimensions with given initial data and prescribed boundary conditions.
The technique is generalized to non-linear parabolic equations.
It is stable for all mesh ratios, and it is second order accurate...
By salt depleting the animals or by injecting them with
aldosterone, I was able to increase the active transport of sodium
across the isolated skin. The potential difference was increased
by 37% and 43% respectively and the net sodium flux by 69% and
62%. Exposure of frogs to 50 mM...