In a search for new therapeutic agents, a series of Mannich bases
derived from the following 2-phenylindolizines were prepared: 2-phenylindolizine, 1, 2-diphenylindolizine, 3-methyl-2-phenylindolizine,
3-ethyl-2-phenylindolizine, and 1-(2-hydroxyethyl)-2-phenylindolizine.
The investigation was based on the speculation that indolizine
analogs of physiologically active indoles might be useful medicinally.
A certain group of indoles, all...
A cell-free system for assessing the role of S-adenosyl-methionine
in the methylation of homocysteine deriving the methyl
group from serine has been developed. No role for S-adenosyl-methionine
could be shown in the in vitro reaction
The enzyme serine transhydroxymethylase has been studied in
crude and partially purified cell extracts. Evidence...
Aseptic radiorespirometry has been used to examine
the utilization of external carbon sources by proliferating
Thiobacillus thioparus cells. These studies reveal
that glucose, galactose, mannose, fructose, ribose, DL-glutamate,
and L-aspartate were not utilized by this
chemoautotrophic organism. However, it has been shown
that trace amounts of acetate, glycine, DL-serine, DL-alanine,...