Aseptic radiorespirometry has been used to examine
the utilization of external carbon sources by proliferating
Thiobacillus thioparus cells. These studies reveal
that glucose, galactose, mannose, fructose, ribose, DL-glutamate,
and L-aspartate were not utilized by this
chemoautotrophic organism. However, it has been shown
that trace amounts of acetate, glycine, DL-serine, DL-alanine,...
A cell-free system for assessing the role of S-adenosyl-methionine
in the methylation of homocysteine deriving the methyl
group from serine has been developed. No role for S-adenosyl-methionine
could be shown in the in vitro reaction
The enzyme serine transhydroxymethylase has been studied in
crude and partially purified cell extracts. Evidence...
In a search for new therapeutic agents, a series of Mannich bases
derived from the following 2-phenylindolizines were prepared: 2-phenylindolizine, 1, 2-diphenylindolizine, 3-methyl-2-phenylindolizine,
3-ethyl-2-phenylindolizine, and 1-(2-hydroxyethyl)-2-phenylindolizine.
The investigation was based on the speculation that indolizine
analogs of physiologically active indoles might be useful medicinally.
A certain group of indoles, all...