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Filtering by: Advisor Bond, F. Thomas Remove constraint Advisor: Bond, F. Thomas Decade 1960-1969 Remove constraint Decade: 1960-1969

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  • Steroid-dihalocarbene reactions

    Creator:
    Damewood, John Roderick
    Abstract:
    Dihalocarbenes have been generated by thermal decomposition of sodium trichloroacetate and tribromomethylphenylmercury, and give mono dihalocyclopropyl adducts with steroid dienes. Such compounds offer an easy starting point for the synthesis of unusual derivatives of potential biological interest. Under the same conditions, however, addition to non-conjugated double bonds does not take...
    Resource Type:
    Masters Thesis
    Full Text:
    Dr. F. Thomas Bond for his guidance and assistance in the preparation of this thesis. TABLE OF

  • Decomposition of di-p-toluenesulfonyl-hydrazones

    Creator:
    Bradway, Diane Elizabeth
    Abstract:
    Thermal decomposition of several di-p-toluenesulfonylhydrazones was studied. It was found that the carbene decomposition of tetramethyl-1,3-cyclobutanedione, di-p-toluenesulfonylhydrazone gave two products resulting from rearrangement. One was identified as 2,5-dimethyl-1,3,4-hexatriene. A tentative structure for the second was proposed. During the course of the study, a more convenient procedure for thermal decompositions was...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF T}iE TI{ESIS OF f or the M.S. inDiane

  • Chemistry of cyclobutane compounds

    Creator:
    Musa, Willie Edsel
    Abstract:
    Examination of a proposed reaction scheme to prepare bicyclo-(2.2.0)hexan-1-ol produced the first known condensation of an enamine with its carbonyl precursor. Hydrolysis of the resulting dienamine gave an unusual conjugated cyclobutenone in which the double bond is exocyclic. Characterization and reactions of the cyclobutenone were successfully carried out.
    Resource Type:
    Masters Thesis
    Full Text:
    (ltr5 ACKNOWLEDGEMENT The author wishes to express his appreciation to Dr. F.. Thomas Bond for his

  • Steroid organoborane reactions

    Creator:
    Byall, Elliott Bruce
    Abstract:
    Steroid organoboranes have been found to be useful synthetic intermediates. Attempted pyrolyses, based on simple trialkylborane cyclizations, have not yielded C-19 or C-18 functionalized steroids, but have produced isomerized systems not otherwise available. Thus, hydroboration of cholesterol followed by pyrolysis at 215° gives 31% of 2-cholestene-6α-ol and 49% of a...
    Resource Type:
    Dissertation
    Full Text:
    my greatest appreciation and gratitude. I am also largely indebted to Dr. F. Thomas Bond, whose

  • Formation of alkyl-and dialkylcarbenes. The 3-cyclohexenyl carbinyl carbene system

    Creator:
    Crouse, Dale McClish
    Abstract:
    The 3-cyclohexenyl carbinyl carbene species was formed by the thermal decomposition of the p-toluenesulfonylhydrazone sodium salt and by oxidation of the hydrazone. Several oxidizing agents were studied. The products were investigated under aprotic and protic conditions and at various temperatures. The diazocompound was formed as an intermediate and found to...
    Resource Type:
    Masters Thesis
    Full Text:
    Gwendolyn Hansen ACKNOWLEDGEMENTS I wish to express my appreciation to Dr. F. Thomas Bond for his

  • The synthesis and chemistry of strained bicyclic systems

    Creator:
    Scerbo, Louis
    Abstract:
    A facile route to bicyclo(2.1.1)hexanes was developed involving the intramolecular photocyclization of 1, 5-hexadien-3-one to bicyclo(2.1.1)hexan-2-one. A study of the chemistry of bicyclo-(2.1.1)hexan-2-one was undertaken. Deuterium exchange and borohydride reduction demonstrated the strain present in the ketone. Further evidence was obtained from the failure to introduce substituents alpha to the...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved Dr. F. Thomas Bond A facile route to bicyclo(2. 1. 1)hexanes was developed involving

  • Some synthetic efforts in small ring chemistry

    Creator:
    Lam, Luke Kwok Tung
    Abstract:
    Cyclopropylcyclobutene was prepared via the intermediate dicyclopropylcarbinyl carbene which was generated by the thermal decomposition of the sodium salt of dicyclopropylketone p-toluenesulfonylhydrazone. The successive thermal isomerization of cyclopropylcyclobutene to 2-cyclopropyl-1, 3-butadiene and to vinylcyclopentene was studied. Kinetic data were obtained for the cyclopropylcyclobutene to 2-cyclopropyl-1, 3-butadiene isomerization in the gas...
    Resource Type:
    Masters Thesis
    Full Text:
    The author wishes to express appreciation to Dr. F. Thomas Bond for his continued interest and

  • Reactions of organoboranes

    Creator:
    Thompson, Thomas Myron
    Abstract:
    An examination was made of some reactions involving a transfer of carbon from boron to carbon. In the case of the reaction of a C[subscript n] alkylorganoborane with dichlorocarbene the intermediate was a C[subscript n]₊₁ chloroalkylorganoborane. Oxidation of this intermediate yielded an homologous acid (33%) and the usual alcohol (66%)....
    Resource Type:
    Masters Thesis
    Full Text:
    Grossnicklaus ACKNOWLEDGEMENT The author wishes to express his most sincere appreciation to Dr. F. T

  • Conformation and reactivity studies of some bicyclo(3.3.1) nonane derivatives

    Creator:
    Sturmer, David Michael
    Abstract:
    New syntheses for 2-bicyclo(3.3.1)nonanone and 7-bicyclo-(3.3.1)nonen-2-one were developed. The saturated ketone was prepared from phenol and acrylonitrile via a novel intramolecular S[subscript N]2 cyclization process. A Friedel-Crafts cyclization of 3-(3-cyclohexenyl)propanoyl chloride permitted synthesis of the unsaturated ketone from 4-cyclohexene carboxaldehyde. The formation of the bicyclo(3.3.1)nonane rather than a bicyclo(3.2.2)nonane skeleton...
    Resource Type:
    Dissertation
    Full Text:
    HISTORICAL 3 Synthesis of Bicyclo(3. 3. 1)nonanes 3 Current Methods 3 Double Bond Participation in

  • Dihalocarbene reactions with steroid olefins

    Creator:
    Cornelia, Richard Hartman
    Abstract:
    Dihalocarbenes have been generated mainly by thermal decomposition of sodium trihaloacetate and phenyl (trihalomethyl)mercury, and give gem-dihalocyclopropyl adducts with various steroid olefins. A new procedure involving the use of sealed tubes makes possible the addition of dihalocarbenes to sterically hindered olefins. In this manner, 7-cholestenyl benzoate when treated with PhHgCC1₃...
    Resource Type:
    Dissertation
    Full Text:
    have been a constant comfort during the years this work was in progress. Thanks are also due to Dr. F