Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
Electrical stimulation of the vagus nerves produces an excitatory
contraction response in the isolated rat stomach. This contraction
response was abolished by atropine to unmask the vagal inhibitory
response (VIR) elicited during low frequency vagal stimulation.
Babring and Gershon (1967), after working on guinea-pigs and mice,
hypothesized that both serotonin...
Dietary fiber has been suggested as interfering with
mineral utilization. The influence of broccoli florets and
wastes, cauliflower heads and wastes, wheat bran and Metamucil
on mineral uptake by the rat was determined using
balance studies. All results were compared to control
animals fed diets containing 10% hydrolyzed cellulose.
Utilization...