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Creator:: Sprinker, Lucas Harry
Abstract:: The selenium-responsive syndromes and the discovery of Factor 3-selenium focused attention on selenium in metabolism. Two hypotheses have been advanced to explain the metabolic effect of selenium: 1) substitution or sparing of alpha tocopherol, and 2) a primary role in metabolism. The first hypothesis is supported by Scott and Desai,...
Resource Type:: Masters Thesis
Full Text:: metabolic effect of selenium: 1) substitution or sparing of alpha tocopherol, and 2) a primary role in

Creator:: Johnston, Weldon Kearney
Abstract:: One hundred and fifty-one weanling rats of both sexes were fed control diets or diets containing 160 ppm diethylnitrosamine (DEN) or 150 ppm N-2-fluorenyl-acetamide (FAA). The carcinogen level was calculated so that the LD₅₀ should be achieved at about 17 weeks. Each carcinogen treatment was incorporated with three different diet...
Resource Type:: Masters Thesis
Full Text:: The Effect of Selenium on Chemical Carcinogenicity in the

Creator:: Fischer, William Carl
Abstract:: Selenium deficiency in rats results in increased carbon metabolism, approaching twice the rate of selenium supplemented animals (normal). This is also reflected in a 50 percent increase in lysosomal enzyme activity in tissues of selenium deficient animals. Isolation of rat liver lysosomes shows a 17 percent increase in membrane thickness...
Resource Type:: Dissertation
Full Text:: , 1974 (Major Department) Title: THE EFFECT OF SELENIUM DEFICIENCY ON THE FATTY ACID METABOLISM OF RATS

Creator:: Shull, Lee R.
Abstract:: The metabolism of pyrrolizidine alkaloids and other drugs was studied with regard to nutritional status and species differences. Pyrrolizidine alkaloids which are biotransformed to severely toxic metabolites were isolated from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid crystals containing five alkaloids (senecionine, seneciophylline, jacobine, jacoline, and jacozine) were prepared and found...
Resource Type:: Dissertation
Full Text:: liver weight, but had no effect on microsomal oxidases. Similarly, high copper had no effect on the

Creator:: Whitfield, Stephen Curtiss
Abstract:: The testes of the gray-tailed vole (Microtus canicaudus Miller) exhibited a high affinity for selenium relative to other selected tissues. Uptake of selenium-75 in the testis-epididymis complex was delayed relative to uptake by the whole body, kidney, and liver. This pattern of uptake suggested that selenium was metabolically incorporated into...
Resource Type:: Masters Thesis
Full Text:: E in the diet, the addition of selenium produced no significant changes in measured physiological

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