An enhancement of the therapeutic effect and/or a reduction in
the toxicity have been shown by a variety of antineoplastic compounds
when glucose is added to the treatment schedule. A possible explanation
for this involves a selective change in intracellular pH of the
tumor tissue initiating a greater uptake of...
The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...