The inhibition of S-aden.osylmethionine: Δ²⁴-sterol methyltransferase
(EC 2.1.1.41) activity by endogenous cellular components has
been studied in vitro. The principal inhibitors were Na⁺ and K⁺; Cs⁺,
NH₄⁺ and Li⁺ were also shown to inhibit the reaction. The inhibition
by potassium cation has been studied, and we have found that energy...
The generation of the methyl group of methionine, and is also involved in thymidylic acid and purine biosynthesis. The understanding of the mechanisms and controls involved in one-carbon metabolism is incomplete, and is complicated by the existence of conjugated folate cofactors containing up to seven glutamic acid residues. The information...