Index Catalog // ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: : Product Formulation of Phenylbutazone, Theophylline, Tolbutamide and Pharmacokinetics-Toxicities of

Adenosine receptor modulation of seizure susceptibility in rats

Creator:: Szot, Patricia
Abstract:: Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
Resource Type:: Dissertation
Full Text:: reversed by pretreatment with theophylline. Theophylline alone produced a proconvulsant effect on PTZ

Selenium-75 incorporation in semen and reproductive organs of the bull and ram

Creator:: Pond, Finn Richard
Resource Type:: Dissertation

The effect of food processing on the bioavailability of selenium in tuna and wheat : human and rat studies

Creator:: Alexander, Anne Rose
Abstract:: Bioavailability of selenium (Se) in processed tuna and wheat products was studied in humans and rats. The protein source of the rat diets was torula yeast with Se supplied by either raw, precooked or canned tuna, or whole wheat flour, bread or bran. Sodium selenite was used as a control....
Resource Type:: Dissertation
Full Text:: of Doctor of Philosophy in Poods and Nutrition presented on January 22, 1982 Title: The Effect of

Effect of environmental variables on the structure and function of hemocyanin from Callianassa californiensis (Decapoda: Thalassinidea)

Creator:: Miller, Karen Illman
Abstract:: Oxygen binding behavior and subunit association-dissociation of the hemocyanin from Callianassa are sensitive to several environmental variables. Callianassa californiensis is a burrowing estuarine which must survive changes in salinity, temperature and oxygen availability. Previous work on the structure and function of the hemocyanin was done under conditions which did not...
Resource Type:: Dissertation
Full Text:: Effect of environmental variables on the structure and

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: conceivable that this difference in physiological effect would be magnified during glucose peak

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Creator:: Leid, Mark
Abstract:: Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
Resource Type:: Dissertation
Full Text:: I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Creator:: Devaud, Leslie L.
Resource Type:: Dissertation
Full Text:: ]Ro5-4864 binding to rat olfactory bulb membranes: effect of cismethrin. 16. Schild plot of

Effect of ethanol and low dietary copper on perinatal and postweanling copper utilization in the rat

Creator:: Baek, Jong Ho
Abstract:: The hypotheses of this research were (1) to test if the antagonistic effect of ethanol on liver copper could be seen within a short period when ethanol ingestion, low dietary copper and high metabolic demand represented by either pregnancy plus lactation or rapid growth are simultaneously present and (2) to...
Resource Type:: Dissertation
Full Text:: physiological state (pregnancy and lactation compared to growth); and (5) to determine the effect of maternal

Perinatal and postweaning effects of the interaction between maternal ethanol ingestion and low dietary zinc in the rat

Creator:: Yeh, Lee-chuan C.
Abstract:: This research was designed to study the perinatal and postweaning effects of the interaction between ethanol and low dietary zinc during gestation and lactation in the rat. Pregnant rats were fed liquid diets containing either 2 or 10 μg zinc/ml with or without 30% of kcal from ethanol throughout gestation...
Resource Type:: Dissertation
Full Text:: offspring despite zinc deficiency. Physiological consequences of ethanol-antagonized zinc status were

ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Adenosine receptor modulation of seizure susceptibility in rats

Selenium-75 incorporation in semen and reproductive organs of the bull and ram

The effect of food processing on the bioavailability of selenium in tuna and wheat : human and rat studies

Effect of environmental variables on the structure and function of hemocyanin from Callianassa californiensis (Decapoda: Thalassinidea)

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Effect of ethanol and low dietary copper on perinatal and postweanling copper utilization in the rat

Perinatal and postweaning effects of the interaction between maternal ethanol ingestion and low dietary zinc in the rat

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