Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Subject Streptomyces Decade 1980-1989 Degree Name Doctor of Philosophy (Ph.D.)

Synthesis of two subunits of avermectin B1a

Creator:

Dantanarayana, Anura Pathmasiri

Abstract:

Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...

Resource Type:

Dissertation
Studies on advanced intermediates in the biosynthesis of streptonigrin

Creator:

Erickson, W. Randal

Abstract:

Early studies on the biosynthesis of the quinoline quinone portion of streptonigrin, 1, had suggested the intermediacy of novel aromatic amino acids. In order to test this hypothesis, a series of compounds was synthesized and tested for potential incorporation. [4-¹⁵N] 4-Aminoanthranilic acid, 4 5 a , [4-² H] 7-aminoquinaldinic acid,...

Resource Type:

Dissertation
Biosynthesis of acivicin and 4-hydroxyacivicin

Creator:

Ju, Shyh-chen

Resource Type:

Dissertation