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Filtering by: Subject Theophylline -- Physiological effect Remove constraint Subject: Theophylline -- Physiological effect Decade 1980-1989 Remove constraint Decade: 1980-1989 Subject Adenosine -- Receptors Remove constraint Subject: Adenosine -- Receptors

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  • Adenosine receptor modulation of seizure susceptibility in rats

    Creator:
    Szot, Patricia
    Abstract:
    Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
    Resource Type:
    Dissertation
    Full Text:
    reversed by pretreatment with theophylline. Theophylline alone produced a proconvulsant effect on PTZ

  • Pharmacological characterization of the porcine atrial A₁ adenosine receptor

    Creator:
    Leid, Mark
    Abstract:
    Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
    Resource Type:
    Dissertation
    Full Text:
    I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

  • Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

    Creator:
    Zhang, Ge
    Abstract:
    Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
    Resource Type:
    Masters Thesis
    Full Text:
    effect on PTZ seizures by i.v. injection of 2-C1A was reversed by i.p. pretreatment of theophylline