Recent studies have demonstrated that perturbations of
intracellular thiol and calcium homeostasis may be important events
in the early development of cell injury by toxic chemicals.
Incubation of isolated rat hepatocytes in a calcium free
medium, severely depleted intracellular Ca²⁺ levels and resulted in
the loss of both cytosolic and...
Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion...
The influence of substrate and enzyme concentration on the rate
of saccharification of two defined, insoluble, cellulose substrates,
Avicel and Solka-Floc, by the cellulase enzyme system of Trichoderma
viride has been evaluated. Assays utilized enzyme concentrations
ranging from 0.014 to 0.056 filter paper unit per mL and substrate
concentrations up...
The cholesterol content (mg/100 g wet tissue) of the
longissimus dorsi muscle and the subcutaneous adipose
tissue of "Country Natural Beef" and regularly produced
beef was determined by a spectrophotometric method.
Proximate analysis (moisture, fat and protein contents) of
both types of beef was also determined.
Country Natural Beef (natural...
Because Douglas-fir [Pseudotsuga menziesii(Mirb.)Franco] bark is a raw material produced in our renewable forests along with wood, an understanding of the ultrastructure of bark cells is of paramount importance if wood technologists are to utilize the bark to the fullest potential. The objectives of this study were to develop microscopic...
The effect of reducing sodium chloride in Cheddar cheese was
studied. Milled curd from a split-lot was salted at selected NaCl
concentrations and analyzed through aging by sensory and rheological
tests. Estimation of differences in compositional analysis, lactic
acid populations, degree of proteolysis, water activity, and pH were
also determined....
In spite of imperfections, this monograph is useful in locating bird skins collected along the Oregon Coast that are stored in about 80 museums. This monograph lists over 11,000 records of skins for 279 bird species and 192 records of skeletons for 52 bird species. Each record includes the species,...
The metabolic fate of cholesterol delivered to rat hepatocytes by rat plasma lipoproteins was determined. Binding and degradation of rat low and high density lipoproteins (LDL and HDL) in rat hepatocytes were studied. ¹²⁵I-labelled LDL and HDL were incubated with cells in the presence of varying concentrations of unlabelled lipoproteins...
A two-part study was conducted with three poorly water soluble
drugs (phenylbutazone, tolbutamide, theophylline) to develop two new
drug delivery systems based on physical-chemical approaches.
In the first part, tolbutamide and phenylbutazone were made into
solid dispersions with various excipients using a lyophilization
technique. In vitro dissolution studies of these...