Index Catalog // ScholarsArchive@OSU

Circular dichroism spectroscopy and the conformational analysis of globular proteins in the native and denatured state

Creator:: Compton, Larry A.
Abstract:: A simple matrix method for the analysis of protein circular dichroism (CD) spectra is presented and used to compute the secondary structure of globular proteins in their native and denatured states. The method uses singular value decomposition and generalized inverse algorithms, and a basis set of CD spectra for proteins...
Resource Type:: Dissertation
Full Text:: whose secondary structures are known from x-ray crystallography. Inverse CD functions for five major

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Creator:: Deffo, Tamboue Esaie
Abstract:: In an effort to isolate and characterize cardiac glycosides C-17 binding site(s), we have synthesized different affinity and photoaffinity C-17 side chain probes. These probes were screened for their ability to inhibit Na⁺,K⁺-ATPase enzyme, a pharmacological receptor of cardiac glycosides. The enzyme was isolated from hog kidney. Screening of these...
Resource Type:: Dissertation
Full Text:: CONFORMATION TO BIOLOGICAL ACTIVITY Abstract approved: Redacted for Privacy Dr. D. S. Fullerton In an effort

Structural and synthetic studies of higher terpenoids : Part I. The absolute configuration of (-)-botryococcene : Part II. Total synthesis of (±)-2-desoxystemodinone

Creator:: Somers, Todd Charles
Resource Type:: Dissertation
Full Text:: , which exploited COSY, HETCOR, and long-range HETCOR 2-D NMR techniques, led to a complete proton and

Specific enzymic interactions relating to the mechanism of action on certain 2-chloroethyl nitrosoureas

Creator:: Babson, John Robert
Abstract:: Certain 2- chioroethyl nitrosoureas have been demonstrated to be highly specific inactivators of chymotrypsin in vitro and glutathione reductase, both in vivo and in isolated rat hepatocytes. The inactivation of glutathione reductase in isolated hepatocytes resulted in an increased sensitivity toward an adriamycin induced oxidative challenge. Prolonged incubation of 1-(2-chloroethyl)-3-([1-¹⁴...
Resource Type:: Dissertation
Full Text:: section on nitrosoureas, these methods are far from ideal. Chymotrypsin--A Model System Chymotrypsin

Synthesis of metabolites from the ascomycetes : I. The synthesis and absolute configuration of leptosphaerin : II. Approaches to the synthesis of byssochlamic acid

Creator:: Pallenberg, Alexander J.
Abstract:: Part I. The total synthesis of (+)-leptosphaerin (2), a metabolite of the marine Ascomycete Leptosphaeria Oraemaris (Linder) was achieved, unambiguously establishing both the relative and absolute stereochemistry of this natural product. This synthesis also resolved the long-standing question of which of the isomeric structures 1 or 2 correctly represents the...
Resource Type:: Dissertation
Full Text:: Redacted for privacy Abstract approved: James D. White Part I. The total synthesis of (+)-leptosphaerin

Absolute stereochemistry and total synthesis of botryococcene

Creator:: Reddy, Guvvala Nagabhushana
Abstract:: Studies were carried out to determine the absolute stereochemistry of botryococcene (1). The natural product was degraded to two sets of 'y- and 8- valerolactones. All enantiomeric variations of these lactones were synthesized in optically pure form starting from (S)- and (R)-methyloxiranes. 1H NMR correlation of natural and synthetic materials...
Resource Type:: Dissertation
Full Text:: Botryococcene Abstract approved: Pedacted for Privacy Li James D. White Studies were carried out to determine

Nucleosome instabilities in physiological salt

Creator:: Yager, Thomas D.
Abstract:: Best scan available for figures. Some figures are high gloss photos, others are black and white photocopies.
Resource Type:: Dissertation
Full Text:: Instabilities in Physiological Salt by Thomas D. Yager A THESIS submitted to Oregon State University in

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Wityak, John
Abstract:: The loss of all deuterium labels from previous feedings of [2-²H]-, [3,3-²H₂]-, and [2,3,3-²H₃]arginines had indicated the possible intermediacy of β-hydroxy- and β-ketoarginine (30 and 31, respectively) in the biosynthesis of the streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D,L-[2,3,3,5,5-²H₅]- arginine (32) was...
Resource Type:: Dissertation
Full Text:: streptolidine portion of streptothricin F (la). In order to confirm or refute this evidence, D ,L- [2,3,3 ,5 ,5

Synthesis and structure-activity relationships of some 4-substituted pyrazole and isoxazole inhibitors of liver alcohol dehydrogenase ; The use of molecular connectivity in the multivariate classification of drug molecules

Creator:: Henry, Douglas R.
Abstract:: In a two part thesis, studies were made of two different types of structure-activity relationships. The first part consists of the synthesis and biological evaluation of a number of 4-substituted pyrazoles and isoxazoles as inhibitors of liver alcohol dehydrogenase. In an effort to better define the steric and electronic effects...
Resource Type:: Dissertation
Full Text:: the synthesis and biological evaluation of a number of 4-substituted pyrazoles and isoxazoles as

Structure and properties of new, complex copper and zinc borates

Creator:: Smith, Robert W.
Resource Type:: Dissertation
Full Text:: ) orthoborate b) pyroborate c) metaborate ring d) tetraborate 6 compared to other metaborate anions of

ScholarsArchive@OSU

Circular dichroism spectroscopy and the conformational analysis of globular proteins in the native and denatured state

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Structural and synthetic studies of higher terpenoids : Part I. The absolute configuration of (-)-botryococcene : Part II. Total synthesis of (±)-2-desoxystemodinone

Specific enzymic interactions relating to the mechanism of action on certain 2-chloroethyl nitrosoureas

Synthesis of metabolites from the ascomycetes : I. The synthesis and absolute configuration of leptosphaerin : II. Approaches to the synthesis of byssochlamic acid

Absolute stereochemistry and total synthesis of botryococcene

Nucleosome instabilities in physiological salt

Studies on the biosynthesis of the streptolidine moiety of streptothricin F

Synthesis and structure-activity relationships of some 4-substituted pyrazole and isoxazole inhibitors of liver alcohol dehydrogenase ; The use of molecular connectivity in the multivariate classification of drug molecules

Structure and properties of new, complex copper and zinc borates

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