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Filtering by: Subject Anticonvulsants Remove constraint Subject: Anticonvulsants Decade 1980-1989 Remove constraint Decade: 1980-1989

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  • Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

    Creator:
    Zhang, Ge
    Abstract:
    Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
    Resource Type:
    Masters Thesis
    Full Text:
    and neurochemical basis for the anticonvulsant actions of adenosine have not been well established

  • Adenosine receptor modulation of seizure susceptibility in rats

    Creator:
    Szot, Patricia
    Abstract:
    Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
    Resource Type:
    Dissertation
    Full Text:
    observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA