Pharmacokinetics of theophylline and N-7 substituted
theophylline in rabbits when administered alone and in
various combinations were investigated. This thesis has
four chapters dealing with etophylline and theophylline;
proxyphylline and theophylline; dyphylline and theophylline;
and etophylline, proxyphylline and dyphylline pharmacokinetics
when administered concomitantly. All chapters
are interrelated. Each chapter has...
A two-part study was conducted with three poorly water soluble
drugs (phenylbutazone, tolbutamide, theophylline) to develop two new
drug delivery systems based on physical-chemical approaches.
In the first part, tolbutamide and phenylbutazone were made into
solid dispersions with various excipients using a lyophilization
technique. In vitro dissolution studies of these...
Adenosine is considered to be a neuromodulator or
cotransmitter in the periphery and CNS. This neuromodulatory
action of adenosine may be observed as an anticonvulsant effect.
Dose-response curves for R-phenylisopropyladenosine (PIA),
cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine
(NECA) and S-PIA were generated against
PTZ seizure thresholds in the rat. The rank...
The purpose of this study was to monitor coronary responses
occurring in the S-T segment of an electrocardiogram before, during
and after exercise following a "standard" carbohydrate-loading schedule with varied vitamin B-6 supplementation. The study was conducted
using four college-aged males who had been training a minimum of two
years...
Roughskin newts, Taricha granulosa (Skilton), were exposed to
UV-B (280-320nm), UV-A (321-380 nm), and visible radiation from
fluorescent sunlamps (Westinghouse FS40) that were filtered with
cellulose acetate film. UV-B controls were exposed to irradiation
from sunlamps that were filtered with Mylar-D, a polyester film
that effectively absorbed UV-B radiation while...
Purpose: The purpose of this study was to determine
the effectiveness, if any, of the P0₂ Aerobic Exerciser in
simulating high altitude training in cross country runners
living at sea level.
Procedures: This study was conducted during the 1982
winter term at Oregon State University. Four cross country
runners of...
Bioavailability of selenium (Se) in processed tuna and
wheat products was studied in humans and rats. The protein
source of the rat diets was torula yeast with Se supplied by
either raw, precooked or canned tuna, or whole wheat flour,
bread or bran. Sodium selenite was used as a control....
Normal human skin fibroblast cells were used to study the effect
of zinc supplementation of the media on cell growth and the competitive
binding activity of low density lipoprotein (LDL). Cells were
grown in the media containing Dulbecco's Modified-Eagle Medium (DMEM),
5% (v/v) fetal calf serum (FCS), and various levels...