The induction of drug-metabolizing enzymes is a
complex biochemical process manifested not only by
increases in various cytochrome P-450 isozymes and
related activities, but also by alterations in
endoplasmic reticulum membranes. Little work has been
done to examine how cytochrome P-450 inducing agents
influence other cellular processes, such as
phospholipid...
Three studies were conducted to determine the effects of
cyclopropenoid fatty acids (CPFA) on the membrane components of livers
of rainbow trout (Salmo gairdneri). In the first study, ¹⁴C-sterculic
acid was administered by intraperitoneal injection into rainbow trout
and the trout maintained for 72 hours. The labelled sterculic acid
was...
The DNA repair capabilities of rainbow trout (Salmo gairdneri)
were studied vising the method of autoradiography. Trout were fed a
semi-purified control diet containing 0 ppm, 50 ppm, or 300 ppm
cyclopropenoid fatty acids (CPFA) for 6-9 weeks. Liver slices were
prepared and exposed in vitro to a control treatment,...
Cyclopropenoid fatty acids (CPFA), which are a group of
fatty acids produced by plants of the order Malvales, are known
to induce adverse physiological effects when administered to a
variety of animal species. A structurally strained cyclopropene
ring is present in all CPFA and is believed responsible for the
toxic...
Cyclopropenoid fatty acids (CPFA) are unique compounds that
contain a highly strained and reactive cyclopropene ring structure.
These compounds have been shown to cause a number of toxic effects
in a variety of animals. Rainbow trout (Salmo gairdneri) have
proven to be particularly sensitive to CPFA. Studies have revealed
that...
Studies were conducted to determine the effects of cyclopropenoid
fatty acids (CPFA) on the microsomal membrane of livers of rainbow
trout (Salmo gairdneri). Slab and tube gel electrophoresis of
microsomes from trout fed a CPFA diet (CPFA-microsomes) for varying
time periods showed a decrease in the number of protein bands...
I. Frozen bovine semen samples were measured by flow cytometry
(FCM) to determine if FCM analyses could be useful for sperm quality
evaluation and prediction of bull fertility. Fluorescent dyes
utilized were acridine orange, to measure sperm nuclear chromatin
heterogeneity by quantifying susceptibility of the chromatin to
denaturation, and rhodamine...