The question of how the presence of nucleosomal
packing of DNA modifies carcinogen interaction at
specific sites cannot be answered by studies on whole
chromatin or bulk nucleosomes because of the
heterogeneity of DNA sequences in the particles. This
problem was circumvented by constructing nucleosomes that
are homogenous in DNA-histone...
The rainbow trout (Oncorhynchus mykiss) model
of chemical carcinogenesis is becoming increasingly
important as a supplement to rodent studies. However,
much of the molecular biology of the carcinogenic
response is still unknown in the trout model. The ras
gene family has been implicated in the tumorigenesis of
both spontaneous and...
Indole-3-carbinol (I3C) and butylated hydroxyanisole (BHA), anti-carcinogens
present in the human diet, were tested for their in vivo
and in vitro effect on aflatoxin B₁. (AFB₁) metabolism, and DNA adduct
formation in the rainbow trout. Dietary BHA at either 0.3 or 0.03%
had no effect on the hepatic tumor incidence...
Purpose: The general problem was to determine the relationship between biorhythms and injuries to college football participants representing Oregon State University. Procedures: The population consisted of one hundred and ninty two football players representing Oregon State University who participated in the intercollegiate football seasons of 1981 and 1982. Injury data...
A special case of a parallel multiprocessor scheduling (MP) problem
is investigated. A set of jobs with a known process time and a.resource
requirement is scheduled on machines controlled by processors,and
the total changeover cost between jobs is to be minimized. Each processor
may control up to two machines and...
The slope parameter "a" of the π ° - electromagnetic transition form factor was obtained from a measurement of the partial branching ratio of the Dalitz decay π° - e⁺ e⁻ y into high invariant-mass electron-positron pairs. The experiment was carried out at the TRIUMF cyclotron laboratory. A beam of...
Aflatoxin B₁ (AFB₁) is a mold-produced toxin which has been shown
to be a potent hepatocarcinogen in many animal species. Of the
species studied thus far, rainbow trout have proven to be the most
sensitive. Experiments were conducted to investigate various aspects
of AFB₁ metabolism in this species, including in...