Index Catalog // ScholarsArchive@OSU

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: for Privacy James W. Ayres, Ph.D. In vivo research following ingesting of commercially available

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: Novel Oral Acetaminophen Product Formulation. Abstract approved: ,Redacted for Privacy James W. Ayres

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Creator:: Lee, Beom-jin
Resource Type:: Dissertation
Full Text:: System for Melatonin in Human Sublects. Abstract approved: James W. Ayres, Melatonin (MT

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Creator:: Stevens, Ruth E.
Abstract:: Pharmacokinetic parameters for theophylline and dyphylline were evaluated in horse cerebrospinal fluid (csf) and plasma. Pharmacokinetic parameters did not differ significantly (p > 0.05) at the same dose for either drug when administered alone or concomitantly. Theophylline and dyphylline penetrate horse csf to produce approximately 1/2 the concentrations found in...
Resource Type:: Dissertation
Full Text:: addition, I would like to thank: Dr. James W. Ayres, my major advisor, for his guidance, valuable advice

Pharmacokinetics and pharmacodynamics of: 1) Oral sustained release acetaminophen suspension in children; 2) Potassium chloride in adults

Creator:: Kalns, John Eric
Resource Type:: Dissertation
Full Text:: ., St. Louis, MO.) dissolved in 700 ml 95% ethanol USP. Polyvinylpyrrolidinone (2% w/w), MW 40,000 and

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Creator:: Chou, Joyce Tian-wei
Resource Type:: Dissertation
Full Text:: 0 Al at =, AA Al A 11. w" 'L. .::::':: .i.::::: .;.;';'... wil .... IP11 1111Vatfil ;Taft :ft

Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlations

Creator:: Holt, Kris Edward
Abstract:: This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a...
Resource Type:: Dissertation
Full Text:: standard. 3 CHAPTER 1 DECONVOLUTION IN SUSTAINED-RELEASE FORMULATION by Kris E. Holt and James W

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: received from my Prof. James W. Ayres during my graduate studies. I consider myself privileged to have

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

Creator:: Bani Jaber, Ahmad Kh.
Abstract:: This thesis is compromised of two distinct formulation sections, which are described below: New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Resource Type:: Dissertation
Full Text:: Peptide Nisin jAbstract Approved: James W. Ay es of two distinct formulation sections, which are This

ScholarsArchive@OSU

New acetaminophen products : formulation development and bioavailability

Calcium alginate gels in oral dosage form design

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Pharmacokinetics and pharmacodynamics of: 1) Oral sustained release acetaminophen suspension in children; 2) Potassium chloride in adults

Product formulations and in vitro-in vivo evaluation of 1) topical insect repellent formualtions against mosquitoes; 2) oral sustained release formulations of cefaclor and pentoxifylline in adults

Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlations

Development and in vivo testing of a gastric retention device (GRD) in dogs

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

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