Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
In spite of their importance in many systems, liquid surfaces have been
explored at the microscopic level to a much lesser extent than solids. Most surface
analysis must take place in vacuum, a major drawback for liquids. The technique of
time-of-flight scattering and recoil spectrometry (TOF-SARS) has been applied to...
A change to a warmer, drier climate beginning as early as 1900 was responsible
for triggering a dramatic, rapid retreat of Collier Glacier, Oregon, between 1924 and
1940. Although there was a dramatic decrease in precipitation contemporaneous with this observed "step-function" response of mass loss, it is unclear if climate...
In particle induced desorption-ionization mass spectrometry the strength of an
analyte's signal under a given set of bombardment conditions is usually considered to
be representative of the analytes relative surface activity. This rationale is generally
used to explain differences in the technique's sensitivity between and within various
classes of compound....