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Filtering by: Advisor McFadden, Philip N. Decade 1990-1999

Automethylation : a response to enzyme aging

Creator:

Lindquist, Jonathan A.

Abstract:

This is the first study to explore the ability of an enzyme to recognize and repair spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase (PCM) is known to repair damage that arises from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins during aging. As...

Resource Type:

Dissertation

Full Text:

approved: Philip N. McFadden This is the first study to explore the ability ofan enzyme to recognize
Biologically inspired biosensors from fish chromatophores

Creator:

Young, Jun

Abstract:

This thesis explores the feasibility of using melanophore-based biosensors from Oreochromis niloticus. Melanophores are one type of pigmented cell of the scales and fins of fish that respond in a motile fashion to a diverse range of stimuli. Fish scales were employed as the first step in determining the utility...

Resource Type:

Masters Thesis

Full Text:

Chromatophores Abstract approved: Philip N. McFadden This thesis explores the feasibility of using melanophore
Protein methylation at sites of blood vessel injury

Creator:

Weber, Darin J.

Abstract:

Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...

Resource Type:

Dissertation

Full Text:

Methylation at Sites of Blood Vessel Injury. Abstract approved: Philip N. McFadden Blood vessel injury was