Index Catalog // ScholarsArchive@OSU

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: of 5 x 104 mPa (20 °C), a Kow logP = 2.96, and a Henry's Law constant of 5.7 x 10'6 Pa m3 mol'i (20

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: supplementation are its estrogenic effect as seen in trout and its ability to induce cytochrome P45 Os involved

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: promotes subcellular distribution of SR-BII to murine hepatic microsomes while having no effect on liver

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Creator:: Kim, Min-Sun
Abstract:: Hydrocarbon solvents are widely used in the production of paints, adhesives, dyes, polymers, plastics, textiles, printing inks, agricultural products and pharmaceuticals. While the neuropathic potential of aliphatic solvents was shown in the 1970s, little is known about the neuropathic potential of aromatic solvents. The present study examines such solvents, 1,2-diethylbenzene...
Resource Type:: Dissertation
Full Text:: 3.1 In-vitro effect of diacetylbenzene isomers on test proteins bovine serum albumin and ribonuclease

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:: Ruby, Carl E.
Abstract:: In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Resource Type:: Dissertation
Full Text:: .................................................................................. Tab'e of Contents (Continued) Page Chapter 4: Effect of 2,3,7,8 Tetrachlorodibenzo-p-Dioxin on Nitric

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: DIM exposures in rodent models to further elucidate the effect these compounds might have on health

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Creator:: Wang, Qi
Abstract:: Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
Resource Type:: Masters Thesis
Full Text:: phosphoribosyltransferase) genes as selectable markers showed that most X ray- 9 induce mutations arise from deletions

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: , 2007. Title: Chlordecone (CD), A Mixed Steroid X Receptor (SXR) and Estrogen Receptor alpha (ERα

Bioaccumulation profiles of chemical contaminants in fish from the lower Willamette River, Portland Harbor superfund site and human health risk assessment

Creator:: Sethajintanin, Doolalai
Abstract:: Concentrations of twenty-five PCBs, fifteen organochiorine pesticides and mercury were determined in recreational fish from the Willamette River, Oregon during the summer of 2000. Thirty-six fish samples of three fish species including black crappie, smalimouth bass and con-rn-ion carp were analyzed. The data reported here provides new information and recent...
Resource Type:: Masters Thesis
Full Text:: biological and physiological data of fish sample 23 TEQ concentrations (pg/g, wet weight) in whole fish .33

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: . Effect of pH on cEH activity using TSO as substrate for cytosol ..................21 3.3. Effect of pH

ScholarsArchive@OSU

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Bioaccumulation profiles of chemical contaminants in fish from the lower Willamette River, Portland Harbor superfund site and human health risk assessment

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

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