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Filtering by: Creator Collins, Ron L. Remove constraint Creator: Collins, Ron L. Decade 2000-2009 Remove constraint Decade: 2000-2009 Degree Level Bachelor's Remove constraint Degree Level: Bachelor's Subject Colon (Anatomy) -- Cancer -- Genetic aspects Remove constraint Subject: Colon (Anatomy) -- Cancer -- Genetic aspects

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  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    previously (36). Cells were maintained with 10% or 15% complete media (CM) (DMEM with 4.5 g/L L-glutamine