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Filtering by: Decade 2000-2009 Degree Level Doctoral Language English [eng] Rights Statement Copyright Not Evaluated Subject Deoxyribonucleotides -- Synthesis

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:

Song, Shiwei

Abstract:

It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...

Resource Type:

Dissertation
The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Creator:

McGaughey, Kathleen M.

Abstract:

The faithful replication of DNA depends on the appropriate balance of DNA precursors. From studies conducted in bacteriophage T4, models for deoxyribonucleotide biosynthesis producing pools appropriate for DNA replication have made it possible to understand more complex systems. A portion of that body of evidence supports the concept that deoxyribonucleotide...

Resource Type:

Dissertation
Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:

Kim, JuHyun

Abstract:

With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...

Resource Type:

Dissertation

ScholarsArchive@OSU

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

The effects of protein associations on pyrimidine deoxyribonucleotide biosynthesis

Organization of the T4 dNTP synthetase complex at DNA replication sites

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