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Filtering by: Subject Time-of-flight mass spectrometry Remove constraint Subject: Time-of-flight mass spectrometry Decade 2000-2009 Remove constraint Decade: 2000-2009 Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • A new technique for high performance tandem time-of-flight mass spectrometry

    Creator:
    Katz, Daniel Louis
    Abstract:
    The main result of this written dissertation is a mathematical solution to the problem of multiplex recording for high performance tandem time-of-flight mass spectrometry. The prescription is to use a time-lag accelerator in the second stage to match the ion optical properties of the decay fragments to the requirements of...
    Resource Type:
    Dissertation
    Full Text:
    Technique for High Performance Tandem Time-of-Flight Mass Spectrometry. Abstract approved. Douglas F

  • Time-of-flight direct recoil spectrometry : application to liquid surfaces and steps toward quantification

    Creator:
    Tassotto, Michael
    Abstract:
    Liquid surfaces are very abundant in nature. Despite the importance of the liquid interface in general, experimental molecular-level data was almost completely lacking prior to the last decade and a half. The intent of this work is to provide a means by which experimental data on the composition of liquid...
    Resource Type:
    Dissertation
    Full Text:
    basic idea is identical to the one exploited in time-of-flight secondary ion mass spectrometry (TOP

  • Surface composition and orientation of room temperature ionic liquids

    Creator:
    Law, George
    Abstract:
    In this thesis, we investigated the surface composition and orientation of both pure room-temperature ionic liquids (Ils) and binary mixtures of the ILs of the type consisting of the 1-alkyl-3-methylimidazolium ([C[subscropt n]mim]⁺, n=4, 8, and 12) cation coupled with either [PF₆]⁻, [BF₄]⁻, [Cl]⁻, or [Br]⁻. The surfaces of the ILs...
    Resource Type:
    Dissertation
    Full Text:
    and recoiling spectrometry (TOF-SARS), and time-of-flight direct recoil spectrometry (TOF-DRS). The

  • Characterization of UV-crosslinked protein-nucleic acid interfaces by Maldi MS and ESI MS/MS

    Creator:
    Gafken, Philip R.
    Resource Type:
    Dissertation
    Full Text:
    MALDI MS AnaJysis of hRPA7O x dT30 Nucleopeptides ......... 181 6.1.8 Tandem Mass Spectrometry of

  • Gas-phase fragmentation chemistry of protonated peptide ions

    Creator:
    Bythell, Benjamin James
    Abstract:
    The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
    Resource Type:
    Dissertation
    Full Text:
    …………………..............………....... 7 1.2.3.3 Time-of-flight Mass Spectrometry ………………….................... 8 1.2.3.3.1 MALDI

  • Development of fragmentation techniques in mass spectrometry for biological applications

    Creator:
    Ji, Hong
    Abstract:
    In this dissertation, I present the work of developing more efficient and economical techniques for fragmenting large bio-molecules, and ultimately making mass spectrometry a more powerful tool in proteomics, DNA sequencing, and other areas of biomolecular analysis. Aiming at lowering the installation and operating cost, and delivering electron capture dissociation...
    Resource Type:
    Dissertation
    Full Text:
    of ions in many other types of mass spectrometers, including time-of-flight and quadrupole

  • Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

    Creator:
    Wu, Jianyong
    Abstract:
    The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
    Resource Type:
    Dissertation
    Full Text:
    , Brian Arbogast, Jeff Morre and the rest of the mass spectrometry group for their support. Thanks are