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Filtering by: Subject Nucleic acids Decade 2000-2009 Degree Name Doctor of Philosophy (Ph.D.)

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:

Thompson, Cynthia Sue

Abstract:

The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...

Resource Type:

Dissertation

Full Text:

peptidyl-tRNA and transfers the nascent polypeptide chain to the next amino acid on the aminoacyl-tRNA
Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:

Hicks, Joshua M.

Abstract:

This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...

Resource Type:

Dissertation

Full Text:

: Analysis of Secondary Structures in Nucleic Acid Binding Proteins and Nuclear Magnetic Resonance