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Filtering by: Decade 2000-2009 Resource Type Dissertation Rights Statement Copyright Not Evaluated Subject Tetrachlorodibenzodioxin

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:

Choi, Jin-Young, 1964

Abstract:

Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...

Resource Type:

Dissertation
Investigations into the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression: effects on dendritic cell phenotype and function

Creator:

Vorderstrasse, Beth A.

Abstract:

T cell-dependent immune responses are highly sensitive to suppression by exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), yet direct effects of TCDD on T cells have been difficult to demonstrate. Because the activation of naive T cells is initiated by dendritic cells (DC), the studies presented in this dissertation were...

Resource Type:

Dissertation
T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:

Dearstyne, Erica A.

Resource Type:

Dissertation