Index Catalog // ScholarsArchive@OSU

Quantitative determination of emerging contaminants, solvent stabilizers and fullerene nanomaterials, in biological and environmental systems

Creator:: Isaacson, Carl W.
Abstract:: To determine the impact of emerging environmental contaminants on human and environmental health, quantitative analytical methods are required. Analysis of emerging contaminants is hampered by their widely varying physical-chemical properties. Therefore quantitative analytical methods must be developed to determine the behavior of emerging contaminants in environmental systems. A quantitative analytical...
Resource Type:: Dissertation
Full Text:: . QUANTIFICATION OF FULLERES BY LC/ESI-MS AND ITS APPLICATION TO IN VIVO TOXICITY ASSAYS................ 82

Process segmentation and modelling applied to time series featuring the response of biological materials to toxic agents

Creator:: Teng, Angela
Abstract:: The detection of biological and chemical toxins has become one of the main concerns in environmental and military fields. In this framework, the department of Microbiology and Biochemistry at Oregon State University has discovered that fish living cells are promising indicators of the presence of a wide range of toxins....
Resource Type:: Masters Thesis

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Creator:: Usenko, Crystal Y.
Abstract:: Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
Resource Type:: Masters Thesis
Full Text:: nanomaterials. To establish the zebrafish as a rapid assay for testing nanomaterial toxicity, three carbon

Immune responses of juvenile chinook salmon (Oncorhynchus tshawytscha) to p,p-̓DDE and tributyltin

Creator:: Misumi, Ichiro
Abstract:: In this thesis, we examined the effects of the exposures to anthropogenic pollutants on the fish, primarily juvenile chinook salmon, immune system using newly and recently developed immune assays. In addition, we developed a new assay for measuring immunocompetence of fish. In the first chapter, the Alamar Blue assay was...
Resource Type:: Masters Thesis
Full Text:: granulocytes because they overlap in size (Figure 1.2 d). TOXICITY OF ALAMAR BLUE Following dilution of cell

The effect of chronic exposure of chinook salmon to benzo(a)pyrene and cortisol of CYP1A1 induction and susceptibility to a microsporidian parasite, Loma salmonae

Creator:: Marie, Amarisa
Abstract:: Wild populations of fish are faced with a multitude of stressors, which may include human interaction, toxins, and disease. Benzo(a)pyrene (BaP), a known carcinogen and immunotoxin, has been reported in the stomach contents of juvenile chinook salmon, Oncorhynchus tshawytscha, in urban waterways. We investigated the impact of chronic dietary exposure...
Resource Type:: Masters Thesis
Full Text:: explanation for no high BaP dose effect on disease susceptibility may be due to toxicity of BaP directly on

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: explain the toxicity of these compounds. Specifically examining how markers of oxidative stress (F2

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Creator:: Warner, Kara E.
Abstract:: Natural and synthetic estrogenic compounds detected in surface waters have been linked to endocrine signaling disruption in several species. Endogenous estrogen contributes to cartilage and bone deposition during development in vertebrates, and is susceptible to perturbation from xenoestrogens. The goals of this work were to develop a teleost model to...
Resource Type:: Dissertation

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: decreasing the bioavailability of soft nucleophiles or a toxicity effect due to inhibition or modulation of

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: sinusoidal wave pattern. An extended time-course experiment would be necessary for testing this hypothesis

ScholarsArchive@OSU

Quantitative determination of emerging contaminants, solvent stabilizers and fullerene nanomaterials, in biological and environmental systems

Process segmentation and modelling applied to time series featuring the response of biological materials to toxic agents

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Immune responses of juvenile chinook salmon (Oncorhynchus tshawytscha) to p,p-̓DDE and tributyltin

The effect of chronic exposure of chinook salmon to benzo(a)pyrene and cortisol of CYP1A1 induction and susceptibility to a microsporidian parasite, Loma salmonae

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

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