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Creator:: Zhang, Wei
Abstract:: Amphidinolide B₁ is one of the most potent cytotoxic compounds in the amphidinolide family. Its bioactivity and intriguing structure has drawn attention from synthetic chemists. Although numerous synthetic efforts toward the total synthesis of amphidinolide B₁ have been published, it still remains an unconquered synthetic target. One of the unique...
Resource Type:: Dissertation

Creator:: Carlson, Erik
Abstract:: Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: Rich G. Carter Effective methods for the enantiopure formation of

Creator:: Lu, Liang
Abstract:: The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C₁-C₂₆ northern and C₂₇-C₄₀ southern halves. Herein, the synthesis of southern FGHI ring system...
Resource Type:: Dissertation
Full Text:: : Rich G. Carter The structural architecture present in marine toxin azaspiracid - 20

Creator:: Schwartz, Johanna Perkins
Abstract:: A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted biaryls can be produced in just three to four steps from commercially available materials utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will illustrate the ability of mono...
Resource Type:: Dissertation
Full Text:: : Rich G. Carter A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis

Creator:: Ashburn, Bradley O.
Abstract:: An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
Resource Type:: Dissertation
Full Text:: Synthesis Abstract approved: Rich G. Carter An expedient approach to the synthesis

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