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Filtering by: Subject Drug-nutrient interactions Decade 2000-2009

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Creator:

Taur, Jan-Shiang

Abstract:

The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...

Resource Type:

Dissertation

Full Text:

-drug Interaction.......................................4 2.2 Flavonoids
Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Creator:

Fan, Ying

Abstract:

This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...

Resource Type:

Dissertation

Full Text:

reduced the Papp efflux of CSA and increased the Papp absorption of digoxin. The drug-diet interaction
The asymmetric binding of Actinomycin D to DNA hexamers

Creator:

Ivancic, Monika

Abstract:

The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...

Resource Type:

Dissertation

Full Text:

examined using NMR spectroscopy, including drug-bound DNA complexes. Most previous studies of complexes