The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
This dissertation has two objectives. The first objective is to determine where best to situate the study of mentoring (i.e. the 'making of scientists') on the landscape of the history of science and science studies. This task is accomplished by establishing mentoring studies as a link between the robust body...
For the past twenty-seven years, Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) has become a worldwide pandemic. Due to the properties of HIV, such as its fast replication rate and error-prone reverse transcriptase, researchers have been unsuccessful in finding a cure or vaccine. Researchers have, however, developed a treatment regimen...
In this thesis, I studied the translation of dengue virus RNA using a luciferase reporter gene system in Vero cells. The dengue reporter mRNA construct, which harbors 5´-terminal viral nts and 3´-terminal nts, could be translated efficiently compared to an alpha globin reporter construct. The 5´-cap structure and 3´-untranslated region...
John Archibald Wheeler (09 July 1911- ) is a familiar name to physicists and historians of physics alike. Among his many contributions to the corpus of knowledge, in 1939 John Wheeler and Niels Bohr co-authored the first paper on the generalized mechanism of nuclear fission. Beyond that seminal work, Wheeler...
In- stream water temperature is one of the most important environmental
factors associated with the decline in salmonid populations and their habitats in the
Pacific Northwest. Most ecological restoration practices that attempt to reduce instream
temperatures center on replanting or reestablishing riparian vegetation and
increasing flows. However, in a large...
Linus Pauling incorporated hemoglobin and a disease of the blood, sickle cell anemia, into many of his researches between the mid-1930s and mid-1970s. In the early 1930s Pauling became interested in organic chemistry and named hemoglobin as one of the first biochemical substances that he planned to analyze. In 1935...
The United States population continues to increase and diversify. The cultural composition within the United States embodies a multitude of people from a variety of belief systems, religious backgrounds, and ethnicities. Within current biomedical practice, many of these differences are often marginalized, leaving populations with unsatisfactory experiences in seeking health...
Planktonic foraminiferal faunal assemblages were used to estimate sea-surface temperatures (SST) in the southeast Pacific Ocean during the Last Glacial Maximum (LGM) and off the coast of Peru over the last 150,000 years. Temperatures along the eastern boundary of South America were 6-8° C cooler during the LGM than at...