Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
This study co-investigated with students with hidden disabilities the phenomenon of disability identity. This qualitative study utilized phenomenology and strategies proposed by Paulo Freire in an effort to understand identity development specific to individuals with hidden disabilities. There were seven students from a medium-sized, public university who participated in the...
The overarching theme of these stories is the relationship between love and hate, especially the connection between kindness and violence. In this fictional world, love often begets hate, and hate, love: a man's capacity for empathy serves as the catalyst for an act of brutality; a character's loneliness, his desire...
Neurofilament proteins are intermediate filaments found in the neuronal cytoskeleton. Phosphorylation of these proteins is considered important for the assembly and stability of the filaments. Accurate molecular weights have been difficult to measure, largely because the high degree of phosphorylation results in M[subscript r]'S that are significantly greater than dictated...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
Responsible Pedagogy is examination of contemporary education in the United States. Responsible educators are dedicated to being representative, responsive, and respectful. These three principles guide the best teaching and learning that are taking place in classrooms across the country. Launched in 2003, Shakespeare in American Communities is the most ambitious...